Current Member

Mike Dentinger

PhD Student

Office: ISIS 2.05
Telp: +33 368 855 217
FAX:
Email: mike.dentinger@etu.unistra.fr

 

Education

 

2013 – 2015

 

Master of  Sciences (MS) – Chemistry-Biology 13.074/20

University of Strasbourg – Strasbourg, FRANCE

2nd year (2014-2015): 1st Semester : 12.857 Admitted(1st session)

                                           2nd Semester : 14.035 Admitted (1st  session)

1st year (2013-2014): 1st Semester : 12.567 Admitted(1st session)

                                           2nd Semester : 12.838 Admitted (1st  session)

 

 

2013

 

 

 

Licence (3rd year University degree) in Chemistry 11.459/20

University of Strasbourg – Strasbourg, FRANCE

3rd year (2012-2013): 1st Semester : 10.927 Admitted(1st session)

                                           2nd Semester : 12.508 Admitted (1st  session)

2nd year (2011-2012): 1st Semester : 12.238 Admitted (2nd session)

                                           2nd Semester : 10.978 Admitted(1st  session)

1st year (2010-2011): 1st Semester : 10.985 Admitted(1st session)

                                           2nd Semester : 11.025 Admitted (1st  session)

1st year  (2009-2010): 1st Semester : 8.307 Adjourned (2nd session)

                                           2nd Semester : 7.985 Adjourned (2nd session)

 

 

2009

 

Baccalauréat Général (French High school diploma)

Lycée Louis Pasteur – Strasbourg, FRANCE

 

Scientific Skills

 

 

  •  Synthesis of organic and inorganic compounds
  • Use of different purification methods (column chromatography, recrystallization, ultracentrifugation…)
  • Physical analysis and characterizations (RMN, IR, TGA, XPS, SEM…)
  • Take care of a different cell line and sample preparation for confocal microscopy and flow cytometry
  • Interpretation of the different analysis data
  • Redaction of the different results like a scientific publication
  • Software :  Microsoft  Word,  Excel  et  Power  Point, Image J and also some software use in chemistry like ChemDraw, NMR NoteBook …

 

Work Experience in Chemistry

 

 

 

November 2015 - Actually

 

 

 

 

January 2015- June 2015

 

 

PhD

Laboratoire de Chimie et de Biomatériaux Supramoléculaires under the supervision of Prof. Luisa De Cola - University of Strasbourg - FRANCE

Breakable nanocapsules for the in-vitro and in-vivo delivery of biomolecules

 

Master 2 internship

Laboratoire de Chimie et de Biomatériaux Supramoléculaires under the supervision of Prof. Luisa De Cola and Dr. Ingrid Cabrera-Puig - University of Strasbourg - FRANCE

Influence of the functionalization in the physicochemical properties and in vitro behavior of breakable mesoporous silica nanoparticles.

 

 

 

March 2014 – June 2014

 

Master 1 internship

Laboratoire de Chimie et de Biomatériaux Supramoléculaires under the supervision of Prof. Luisa De Cola and Dr. Laura Maggini - University of Strasbourg - FRANCE

Synthesis of bioconjugated nanozeolites to develop a new cancer therapy in association with the Hospital of Strasbourg.

 

 

July 2013 – September 2013

 

 

Volontary internship

Laboratoire de conceptions et d’analyses de molecules bioactives with Dr. Alexandre Specht

Synthesis of two-photon uncaging systems

 

Presentations and Awards

 

·       Flash and poster presentation at the European Winter School on Physical Organic Chemistry 2016 (1st Prize Poster Award)

Miscellaneous

·       Speaking language: French, English, Spanish (basis)

·       Driving license since September 5th 2010

·       Activity: Basket-Ball, Movies, Football…

 

 

A big challenge in medicine is to be able to create efficient carriers to deliver drugs and/or nucleic acids and to destroy or excreted them from the body. In particular for cancer therapy, also the targeting is still a dream. We developed stimulus responsive porous nanoparticles that can deliver drugs and breaks in small pieces after cell internalization.

Recently, a new generation of organo-hydrid mesoporous silica nanoparticles (NPs) containing redox responsive disulfide (S-S) bridges (ss-NPs) have been developed in our group. We now show how we can functionalize with targeting ligands the surface to have a better penetration for cancer cells without preventing the breakability properties of the material.